Changes in rat spatial learning and memory as well as serum exosome proteins after simultaneous exposure to 1.5 GHz and 4.3 GHz microwaves

Authors: Wang H, Liu Y, Sun Y, Zhao L, Dong J, Xu X, Wang H, Zhang J, Yao B, Zhao X, Liu S, Zhang K, Peng R

Year: 2022 Sep 15

Category: Ecotoxicology

Journal: Ecotoxicology and Environmental Safety

Institution: Ecotoxicol Environ Saf

DOI: 10.1016/j.ecoenv.2022.113983

URL: https://www.sciencedirect.com/science/article/pii/S0147651322008235?via%3Dihub

Abstract

Overview

This study specifically aimed to uncover the effects and identify biological targets sensitive to simultaneous exposure to 1.5 GHz and 4.3 GHz microwaves in Wistar rats.

Findings

  • A total of 120 male Wistar rats were divided into four distinct groups:
    • Sham (S group)
    • 1.5 GHz microwave exposure (L group)
    • 4.3 GHz microwave exposure (C group)
    • Simultaneous 1.5 GHz and 4.3 GHz microwave exposure (LC group)
  • Experiments included:
    • Morris Water Maze for spatial learning and memory assessment
    • Electroencephalography for cortical electrical activity
    • Transmission electron microscopy for hippocampal ultrastructure analysis
  • The significant findings suggest:
    • Impaired spatial learning and memory in microwave exposed groups, notably L and LC groups
    • Diminished cortical excitability and observable damage to hippocampal ultrastructure
    • A notable differential protein expression in serum exosomes, potentially implicating serious health consequences related to synaptic functions

Conclusion

Exposure to simultaneous 1.5 GHz and 4.3 GHz microwaves severely impairs spatial learning and memory. It also suggests potential biomarkers such as VAMP8, Syn7, and VMAT for assessing microwave radiation exposure effects.

microwave exposure spatial learning memory rat study serum exosome proteins electromagnetic fields health risks
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