2.45 GHz microwave radiation impairs learning, memory, and hippocampal synaptic plasticity in the rat

Authors: Karimi N, Bayat M, Haghani M, Saadi H, Ghazipour GR

Year: 2018 Oct 21

Category: Toxicology

Journal: Toxicol Ind Health

DOI: 10.1177/0748233718798976

URL: https://www.ncbi.nlm.nih.gov/pubmed/30345889

Abstract

Overview

Microwave (MW) radiation is prevalent in our homes and has been associated with potential neurobehavioral disorders. This study aims to explore the impact of 2.45 GHz microwave radiation on the central nervous system, specifically focusing on memory and hippocampal synaptic plasticity.

Study Details

Rats were exposed to 2.45 GHz MW radiation for 2 hours daily over 40 days, with an average power density of 0.016 mW/cm2 and a specific absorption rate of 0.017 W/kg.

  • Behavioral assessments were performed using radial maze and passive avoidance tests.
  • Synaptic plasticity evaluated through field potential recording and hippocampal neuronal density assessed by Giemsa staining.

Findings

The exposure to MW radiation:

  • Significantly impaired learning and memory.
  • Reduced long-term potentiation induction and excitability of CA1 neurons.
  • However, did not affect short-term plasticity and paired-pulse ratio, indicative of glutamate release probability.

    • Hippocampal morphology studies showed a significant decrease in neuronal density within the hippocampal CA1 area.

Conclusion

Exposure to 2.45 GHz microwave radiation had detrimental effects on cognitive functions and synaptic arrangements, meriting further investigation into its safety concerning long-term exposure in residential environments.

microwave radiation neurobehavioral disorders learning memory synaptic plasticity hippocampus rats
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