Changes in intracellular calcium concentration level accompany age-related inhibitions of Long-term potentiation in hippocampus induced by Extremely low frequency electromagnetic fields

Authors: Zhao W, Dong L, Tian L, Zhao L, Zhao Y, Zheng Y

Year: 2023 May 18

Category: Neuroscience

Journal: Eur J Neurosci

DOI: 10.1111/ejn.16046

URL: https://pubmed.ncbi.nlm.nih.gov/37203290/

Abstract

Overview

Extremely low frequency electromagnetic fields (ELF-EMFs) have been studied for their impact on learning and memory functions, especially in different stages of development.

Findings

  • The study examines the effects of 15 Hz/2 mT ELF-EMFs on Long-term potentiation (LTP) in the hippocampal CA1 region of young Sprague-Dawley rats at various developmental stages (8, 15, 22, and 29 days old).
  • Results indicate a differential inhibition of LTP due to age, with younger ages showing more significant effects.
  • The inhibitory effect of ELF-EMFs on LTP was reversed by the application of 2-Aminoethoxydiphenyl borate (2-APB), suggesting a role of IP3 Rs-mediated intracellular calcium stores.
  • Variations in the extracellular calcium concentration also influenced the inhibitory effects, displaying different results based on the age of the rats.

Conclusion

This study highlights the intricate mechanisms by which ELF-EMFs affect synaptic plasticity in the hippocampal CA1 area during early development, offering insights for safer application and protection strategies against ELF-EMFs.

ELF-EMFs hippocampus synaptic plasticity intracellular calcium Long-term potentiation electrophysiology age-related changes
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