Effects of exposure to extremely low frequency electromagnetic fields on hippocampal long-term potentiation in hippocampal CA1 region

Authors: Zheng Y, Cheng J, Dong L, Ma X, Kong Q

Year: 2019 Jul 31

Category: Neuroscience

Journal: Biochemical and Biophysical Research Communications

Institution: Biochem Biophys Res Commun

DOI: 10.1016/j.bbrc.2019.07.085

URL: https://www.ncbi.nlm.nih.gov/pubmed/31376941

Abstract

Overview

Exposure to environmental electromagnetic fields, particularly extremely low-frequency (ELF < 300 Hz) electromagnetic fields (EMFs), might affect neuronal activity. These fields are especially of concern due to their potential influence on crucial neural processes.

Findings

  • The study focused on the effect of ELF-EMFs on long-term potentiation (LTP) in the hippocampal CA1 region of rats.
  • Various frequencies (15, 50, 100 Hz), intensities (0.5, 1, 2 mT), and durations (10 s, 20 s, 40 s, 60 s, 5 min) of EMF exposure were tested.
  • Results indicated that LTP amplitudes decreased after exposure to magnetic fields, with the decrease being dose and duration-dependent.
  • The maximum inhibitory effect on LTP was observed with a 5 min exposure at 15 Hz/2 mT.

Conclusion

This study highlights the modulatory effects of ELF-EMFs on synaptic plasticity, suggesting potential risks to learning and memory and implications for neurological health.

ELF-EMFs hippocampal CA1 long-term potentiation synaptic plasticity neurological diseases
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