Short-Term Extremely Low-Frequency Electromagnetic Field Inhibits Synaptic Plasticity of Schaffer Collateral- CA1 Synapses in Rat Hippocampus via the Ca 2+/Calcineurin Pathway

Authors: Pei Xia, Yu Zheng, Lei Dong, Chunxiao Tian

Year: 2021 Sep 9

Category: Neuroscience

Journal: ACS Chem Neurosci

DOI: 10.1021/acschemneuro.1c00500

URL: https://pubmed.ncbi.nlm.nih.gov/34498467/

Abstract

Overview

In this study, we explore how extremely low-frequency electromagnetic fields (ELF-EMF) impact the neural mechanisms in the Schaffer collateral-CA1 (SC-CA1) region of the rat hippocampus.

Findings

  • ELF-EMF modifies synaptic plasticity, diminishing long-term potentiation and boosting long-term depression.
  • Key receptors like voltage-gated calcium channels and the protein calcineurin are crucial to these effects.
  • Blocking these receptors with cadmium chloride and cyclosporin A negates the effects of ELF-EMF, confirming the role of the Ca2+/calcineurin pathway.

Conclusion

This study not only clarifies the effects of ELF-EMF on synaptic behaviors correlated with learning and memory but also introduces a new approach to investigate ELF-EMF’s specific actions on neural pathways.

ELF-EMF synaptic plasticity hippocampus neuroscience Ca2+/calcineurin pathway electrophysiology
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