Abstract

Overview

Mechanical stimuli, such as stretch, shear stress, or compression, activate a range of biomolecular responses through cellular mechanotransduction. In the nervous system, mechanical stress is critical in understanding both traumatic injury and neurodegenerative diseases.

Findings

• The biomolecular pathways triggered by mechanical stimuli in the nervous system are underexplored, making this a pivotal area of study, especially in comparison to other body systems.
• As mechanical and electromagnetic stimulation techniques like ultrasound are increasingly used in psychological and neurorehabilitation treatments, understanding the underlying biological mechanisms is essential for developing accurate pathophysiological models and enhancing therapeutic interventions.

Conclusion

This review summarizes key cellular signaling pathways activated by various mechanical and electromagnetic stimuli, with a focus on the mammalian nervous system. It also briefly discusses the role of potential cellular mechanosensors in these processes.