Extremely Low-Frequency Electromagnetic Field (ELF-EMF) Increases Mitochondrial Electron Transport Chain Activities and Ameliorates Depressive Behaviors in Mice

Authors: Teranishi M, Ito M, Huang Z, Nishiyama Y, Masuda A, Mino H, Tachibana M, Inada T, Ohno K

Year: 2024

Category: Molecular Sciences

Journal: International Journal of Molecular Sciences

DOI: 10.3390/ijms252011315

URL: https://www.mdpi.com/1422-0067/25/20/11315

Abstract

Overview

Depression is often linked to compromised mitochondrial activities. This study explores the effects of enhancing mitochondrial electron transport chain (ETC) activities in managing depressive behaviors.

Findings

  • A low intensity ELF-EMF induces hormetic activation of mitochondrial ETC in various models, including mouse livers and cultured cells.
  • Exposure to ELF-EMF for two to six weeks following chronic social defeat stress (CSDS) significantly ameliorates depressive behaviors in mice.
  • ELF-EMF enhances mitochondrial oxygen consumption and ETC protein levels in the prefrontal cortex, and activates pathways that reduce oxidative stress.

Conclusion

The ELF-EMF is found to positively impact mitochondrial energy production, antioxidation, and dynamics, suggesting its potential as an effective treatment for depression.

mitochondrial electron transport depression ELF-EMF therapeutic options mice model antioxidation
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