The Influence of the Extremely Low Frequency Electromagnetic Field on Clear Cell Renal Carcinoma

Abstract

Overview

The rapid development of technology has led to an increase in the sources of electromagnetic fields (EMF), which are continuously emerging from high-voltage lines to mobile devices. This growth raises concerns about the potential health impacts of EMF exposure.

Key Findings

• The International Agency for Research on Cancer has classified PEM as a possibly carcinogenic factor to humans as of May 31, 2011.
• This study explores the influence of extremely low frequency EMF on clear cell renal carcinoma using in vitro cultures of four specific cell lines: HEK293, 786-O, 769-P, and Caki1.
• Results indicate a varied response from different cell lines, with some showing decreased viability and increased early apoptosis, particularly affected was the 786-O cell line. In contrast, HEK293 cells were not significantly affected by EMF exposure.
• Further findings demonstrate an inhibitory effect of ELF-EMF on the migration and metastatic properties of kidney cancer cells.
• Considerable increases in reactive oxygen species (ROS) levels were observed following ELF-EMF exposure across all tested cell lines.

Conclusion

The study highlights the significant, albeit variable, effects of low-frequency EMFs on the behavior of cancer cells, suggesting a potential role of EMF in modulating cancer cell proliferation, migration, and survival.