Assessment of Inflammation in 3D Reconstructed Human Skin Exposed to Combined Exposure to Ultraviolet and Wi-Fi Radiation

Abstract

Overview

In the human environment, the increasing exposure to radiofrequency (RF) radiation, particularly from wireless devices, presents a potential health risk due to absorption into the body. Combining higher frequency wireless technologies with known harmful solar ultraviolet (UV) impacts posits new questions about skin health.

Findings

This study explored the effects of 2422 MHz Wi-Fi RF exposure, combined with UV radiation on skin inflammation. Through in vitro experiments using a 3D full-thickness human skin model, the inflammation process was examined by analyzing cytokines (IL-1α, IL-6, IL-8) and MMP-1 enzyme secretion.

• The first experiment involved immediate RF exposure following UV exposure to investigate potential additive effects.
• The second experiment analyzed if an adaptive RF exposure prior to UV treatment could offer protective effects.

Conclusion

Results indicated a slight increase in cytokine concentrations following prior UV exposure from Wi-Fi exposure at 2422 MHz, though not significant enough to confirm additive effects. No adaptive response phenomenon was detected, suggesting the need for further investigation on this potential health risk.