Dose- and Time-Dependent Effects of Radiofrequency Electromagnetic Field on Adipose Tissue: Implications of Thermoregulation and Mitochondrial Signaling

Abstract

Overview

Recent studies have illuminated the impact of low-intensity radiofrequency (RF) fields on thermoregulation and metabolism in adipose tissue. This research delves deeper into these aspects by exploring thermoregulatory gene expression and mitochondrial involvement in fat metabolism.

Findings

• Male mice were subjected to 900 MHz RF exposure at specified absorption rates of 0.1 W/kg or 0.4 W/kg.
• Effects observed were both dose-dependent and time-dependent across different types of adipose tissue.
• In brown adipose tissue (BAT), RF exposure reduced thermogenesis and mitochondrial activity, while increasing genes related to reactive oxygen species management. This was somewhat reversed after extended exposure.
• In white adipose tissue (WAT), RF exposure diminished fatty acid oxidation, energy production, and adipocyte differentiation, with no notable effects on mitochondrial biogenesis.

Conclusion

The study underscores complex interactions between RF exposure levels and adipose tissue responses, revealing both detrimental and potentially adaptive changes. Further investigation at the protein level is recommended to better understand these mechanisms and their thresholds.