Electromagnetic field-induced adaptive response in Schwann cells through DNA methylation, histone deacetylation, and oxidative stress

Abstract

Overview

Schwannomas are benign tumors of the peripheral nervous system which mostly arise from alterations in the neurofibromin type 2 gene. This gene codes for the oncosuppressor merlin, associated with the cytoskeleton.

Environmental Challenge

The study addresses environmental impacts, particularly the exposure to electromagnetic fields (EMF) from usual electrical devices potentially causing Schwann cell (SC) transformations, though past evidence was mainly epidemiological.

Methodology

This research uses an in vitro setup simulating EMF exposure (0.1 T, 50 Hz, 10 min) to explore epigenetic mechanisms in SCs adaptation to EMF and associated hypoxic changes post-exposure.

Findings

• Identified alterations in SCs' proliferation and migration abilities post EMF exposure.
• Discussed putative epigenetic mechanisms influencing SCs adaptation to EMF.
• Highlighted the environmental changes in SCs towards a pathological state relevant for SCs differentiation and schwannoma development.

Conclusion

The study provides evidence of epigenetic changes in Schwann cells exposed to EMF, potentially leading to non-physiological and pathological states significant in schwannoma development.