Exposure to 1.8 GHz radiofrequency field modulates ROS in human HEK293 cells as a function of signal amplitude

Authors: Marootpong Pooam, Nathalie Jourdan, Blanche Aguida, Cyril Dahon, Soria Baouz, Colin Terry, Haider Raad, Margaret Ahmad

Year: 2022 Feb 3

Category: Cell Biology

Journal: Commun Integr Biol

DOI: 10.1080/19420889.2022.2027698

URL: https://pubmed.ncbi.nlm.nih.gov/35126804/

Abstract

Overview

The prevalence of the telecommunications industry globally is vast, with a substantial part of the population engaged in daily usage of cell phones. Understanding the potential physiological impacts of GHz range wireless emissions on human health is crucial.

Findings

  • Research highlights the influence of a 1.8 GHz radiofrequency (RF) field at household telecommunications amplitude on ROS (Reactive Oxygen Species) formation in human HEK293 cells.
  • Significant increase in ROS detected via fluorescent imaging after 15 minutes of RF exposure, affecting both nuclear and cytosolic compartments.
  • Modifications in gene expression related to both antioxidative (e.g., SOD, GPX, CAT) and oxidative (Nox-2) enzymes were observed, indicating a multifaceted cellular response.
  • Evidence suggests that genes responsive to static magnetic fields also respond to RF fields, pointing to common response mechanisms.
  • Results indicated hormetic effects, with non-linear biological responses to varying RF signal amplitudes including 'blind' spots where no response was detected.

Conclusion

Exposure to RF fields can modulate intracellular ROS dependent on frequency and amplitude. Such modulation indicates potential both for adverse and beneficial physiological outcomes, underlying the complex nature of RF exposure effects on health.

Radiofrequency ROS Cellular Effects Gene Expression Telecommunications RF Exposure Health Risk
← Back to Stats