Exposure to 1.8 GHz radiofrequency field modulates ROS in human HEK293 cells as a function of signal amplitude
Abstract
Overview
The study highlights a pivotal analysis addressing the effects of radiofrequency (RF) fields, common in modern telecommunications, on biological cells. This is particularly important considering the global everyday use of such technologies.
Findings
- Cells exposed to a 1.8 GHz RF field show increased formation of Reactive Oxygen Species (ROS), detectable by advanced fluorescent imaging.
- Both nuclear and cytosolic areas of the cells demonstrated elevated ROS levels after just 15 minutes of RF exposure.
- Significant alterations in gene expression related to oxidative stress, such as SOD (superoxide dismutase) and Nox-2, were observed.
- RF exposure also influences genes similar to those affected by static magnetic fields, hinting at common cellular response mechanisms to electromagnetic fields.
- The study observed a non-linear, biphasic response in cells to different amplitudes of RF signals, indicating complex biological interactions with RF fields.
Conclusion
Exposure to RF fields like those used in cell phones induces critical changes in cellular ROS levels depending on the frequency and amplitude of the signal. Understanding these effects is essential as they have potential health implications that could be both harmful and beneficial.