Abstract

Overview

Electromagnetic fields (EMFs), particularly at extremely low frequencies, have garnered interest as safe, noninvasive therapies for bone disorders.

Research Development

The study introduces an in vivo model using zebrafish scales to explore the effects of extremely low-frequency electromagnetic fields (ELF-EMFs) on bone healing.

• Experiment Details: Exposure to 10 millitesla (mT) ELF-EMFs at 60 Hz increased the activity of osteoblasts and osteoclasts in zebrafish scales with fractures, while 3 or 30 mT levels did not show these effects.
• Gene Analysis: The upregulation of wnt10b and Wnt target genes was observed, along with enhanced β-catenin expression at the fracture sites.

Findings

Exposure to ELF-EMFs specifically at 10 mT facilitates the activity of both osteoblasts and osteoclasts through the activation of Wnt/β-catenin signaling, which is critical for fracture healing.

Conclusion

The data underscore the facilitative effect of ELF-EMFs on bone fracture healing, validating the therapeutic potential of EMFs especially when generated via a standard commercial AC power supply.