Transcriptomic and Long-Term Behavioral Deficits Associated with Developmental 3.5 GHz Radiofrequency Radiation Exposures in Zebrafish

Authors: Subham Dasgupta, Connor Leong, Michael T Simonich, Lisa Truong, Huaping Liu, Robyn L Tanguay

Year: 2022 Apr 12

Category: Environmental Science and Technology

Journal: Environ Sci Technol Lett

DOI: 10.1021/acs.estlett.2c00037

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009179/

Abstract

Overview

The increasing use of 5G technology has sparked debates regarding its health implications. In this context, the study explores the effects of 3.5 GHz Radiofrequency Radiation (RFR), typical of 5G networks, on zebrafish from development through adulthood.

Findings

  • Developmental exposure to 3.5 GHz RFR from 6 to 48 hours post-fertilization showed no teratogenic effects but led to subtle hypoactivity in startle response assays, indicating possible abnormal sensorimotor behavior.
  • mRNA sequencing revealed modest transcriptomic disruptions at 48 hours post-fertilization, with 28 differentially expressed genes highlighting potential metabolic disturbances.
  • Long-term effects were observed in adulthood, presenting subtle but significant behavioral abnormalities across various assays.

Conclusion

This investigation underscores the need for further research into the developmental impacts of 5G RFR on brain functions, behavior, and metabolism, refuting the notion of its harmlessness and corroborating public health concerns.

radiofrequency radiation 5G zebrafish behavior transcriptomics public health neurobehavioral effects
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