Abstract

Abstract Summary

Overview

The influence of weak radio-frequency electromagnetic field (RF-EMF) on living organisms is increasingly relevant due to the promotion of the Industrial, Scientific, and Medical (ISM) frequency band at 6.78 MHz for mid-range wireless power transfer (WPT) applications. As human exposure to RF-EMF is unavoidable, understanding its effects is critical.

Methodology

This research used in vitro cell culture and molecular biology techniques along with integrated transcriptomic and proteomic analyses to explore the impacts of RF-EMF on cellular and molecular levels.

Findings

• Weak RF-EMF was shown to exert non-thermal effects on human umbilical vein endothelial cells (HUVEC).
• Exposure promotes cell proliferation, inhibits apoptosis, and deregulates ROS balance.
• Alterations in several signaling pathways and key enzymes involved in NADPH metabolism, cell proliferation, and ferroptosis were identified.

Conclusion

The study concludes that current safety standards, which only consider the thermal effects of RF-EMF on cells, are inadequate. It suggests that prompt modifications of existing guidelines and regulations are necessary to protect public health.