Effects of 4G Long-Term Evolution Electromagnetic Fields on Thyroid Hormone Dysfunction and Behavioral Changes in Adolescent Male Mice

Authors: Kim HY, Son Y, Jeong YJ, Lee SH, Kim N, Ahn YH, Jeon SB, Choi HD, Lee HJ

Category: Biomedical Sciences

Journal: Int J Mol Sci

Institution: Int J Mol Sci

DOI: 10.3390/ijms252010875

URL: https://www.mdpi.com/1422-0067/25/20/10875

Abstract

Overview

Radiofrequency electromagnetic fields (RF-EMFs) have the potential to penetrate tissues, influencing endocrine and brain development. Given the rising use of mobile phones among children and adolescents, understanding the long-term effects of RF-EMF exposure on these systems is crucial.

Findings

This study investigated the impact of 4G LTE EMF exposure on thyroid hormone levels and behavior in four-week-old male mice. The mice were exposed to an LTE EMF or a positive control for four weeks, with subsequent testing for behavioral changes and hormonal analysis. Key findings include:

  • Increased T3 levels in the LTE EMF exposed group.
  • Elevation of T3 and T4 and a decrease in ACTH levels due to lead exposure.
  • Significant changes in hypothalamic gene expression affecting the hypothalamus-pituitary-thyroid (HPT) axis in the LTE EMF exposed group.

Conclusion

The study's conclusions highlight potential alterations in the HPT axis due to LTE EMF exposure, underlining the necessity for further research into the broader impacts of RF-EMFs on the endocrine system.

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