Abstract

Abstract Summary

Overview

This study explores the protective effects of long-term exposure to radiofrequency electromagnetic fields (RF-EMF) on cognitive dysfunction in 5xFAD mice, a model for severe late-stage Alzheimer's disease.

Methods

• Mice were exposed to 1950 MHz RF-EMF at a specific absorption rate of 5 W/kg for 2 hours per day, 5 days a week, for 6 months.
• Behavioral tests, molecular analyses, and histopathological examinations of brain tissues were conducted.

Findings

• Therapeutic Effects: RF-EMF exposure reduced amyloid-β deposition and cognitive impairment.
• Microglial Activity: Marked reduction in pan-microglial marker Iba1 and colony-stimulating factor 1 receptor (CSF1R) in treated mice.
• Gene Expression: Analysis showed decreased levels of genes associated with microgliosis and pro-inflammatory cytokine interleukin-1β in RF-EMF exposed groups.

Conclusion

The findings suggest that RF-EMF exposure may offer a therapeutic advantage in reducing Alzheimer's pathology by modulating microglial function and regulating crucial pathways associated with amyloid-β deposition.