Mobile phone EMR affects Amyloid Precursor Protein and α-synuclein metabolism in SH-SY5Y cells

Abstract

Overview

In this study, the effects of low-level, GSM emitted ElectroMagnetic Field (EMF) on Amyloid Precursor Protein (APP) and alpha-synuclein (α-syn) in human neuroblastoma cells were investigated.

Findings

• Observed alterations on APP processing and cellular topology following EMF exposure (𝜀 = 10.51 V/m, SAR = 0.23 W/kg, exposure time: 3 times, for 10 minutes, for 2 days).
• Changes in monomeric α-syn accumulation and multimerization.
• Induction of oxidative stress and cell death documented.

Conclusion

The work seems to be the first report linking exposure to EMF emitted by a transmitting mobile phone, to altered metabolism of APP and α-syn in SH-SY5Y cells. It highlights the increase in monomeric α-syn along with the generation of novel amyloidogenic fragments possessing alternative cellular topology and the induction of cellular toxicity and oxidative stress. Future research should consider these findings in understanding the molecular mechanisms linking EMR to neurodegenerative diseases like Alzheimer's and Parkinson's, suggesting that wireless communications may be a new factor affecting human health.