Evidence of the radiofrequency exposure on the antioxidant status potentially contributing to the inflammatory response and demyelination in rat brain

Abstract

Overview

This study examines the effect of microwave radiation (MWR) exposure on the brain and behavior of Wistar rats. The investigation focused on neurodegeneration linked to MWR exposure under controlled laboratory conditions.

Methodology

The Wistar rats were exposed to 2100 MHz frequency for 4 hours per day, 5 days a week, over 3 months. Microwave exposure parameters included an estimated specific absorption rate of 0.453W/kg and power density of 8.237µW/m2.

Findings

• Increase in serum triglycerides and cholesterol levels.
• Significant oxidative stress observed through altered Glutathione homeostasis.
• Activated pro and anti-inflammatory cytokine responses.
• Significant changes in the myelination pattern and cellular organelles via histopathological assessments and electron microscopic observation.

Conclusion

The study reinforces the concept that 2100 MHz frequency exposure causes oxidative stress leading to immune response modulation, neuronal cell death, and demyelination. These factors collectively contribute to neurodegenerative diseases, demonstrating the impactful multi-hit process of pathogenesis induced by microwave radiation.