Acute exposure of microwave impairs attention process by activating microglial inflammation

Abstract

Overview

Our research aimed to delve into how acute microwave (MW) radiation affects attention processes, given the widespread use and attendant public concerns over its impact.

Background

• Attention is crucial for various cognitive functions and is influenced by environmental factors including MW radiation.

Findings

• The study utilized the five-choice serial reaction time (5-CSRT) task, finding significant impairment in attention among mice exposed to acute MW radiation.
• Analysis of cerebrospinal fluid highlighted neuroinflammatory markers and signs of microglial activation possibly linked to MW exposure.
• Further biochemical analysis in the prefrontal cortex supported these findings, indicating strong microglial activation.
• Treatment with minocycline, an anti-inflammatory agent, showed potential in reducing neuroinflammatory effects and aiding in the recovery of attentional functions post-exposure.

Conclusion

The study concludes that microglial activation and subsequent upregulation of N-Methyl-D-aspartic acid receptors (NMDARs) are key processes in the impairment of attention due to acute MW exposure, suggesting that minocycline may mitigate these effects.