Abstract

Overview

Recent technological advancements have prompted concerns about their potential negative impacts. This study investigates the effects of prenatal exposure to 900 MHz radiofrequency (RF) from mobile phones and evaluates the protective role of linalool in rat offspring.

Methodology

Pregnant rats were grouped into control, wave, wave + linalool, and linalool only. They received linalool (25mg/kg) through gavage for 21 days, concurrent with RF exposure from pregnancy day 0 to 21. Behavioral and electrophysiological assessments were performed on the offspring at 50 and 60 days post-birth.

Findings

• RF exposure induced anxiety-like behavior and impaired learning and memory.
• Decreased synaptic plasticity and electrophysiological function in the dorsal hippocampal CA3-CA1 synapse were noted.
• Trace element disturbances in hippocampal tissue were evident, with altered levels of Fe, Cu, Mn, Zn, and Cu/Zn ratio.
• Linalool treatment mitigated these effects, normalizing trace element levels except for zinc.
• Sex differences were apparent, with female rats showing increased sensitivity.

Conclusion

Prenatal RF exposure adversely affects neurodevelopment, demonstrating stress-like behaviors and cognitive declines in offspring. Linalool shows promise as a neuroprotective agent, suggesting potential strategies for safeguarding against prenatal environmental risks.