Hippocampal Oxidative Stress Induced by Radiofrequency Electromagnetic Radiation and the Neuroprotective Effects of Aerobic Exercise in Rats: A Randomized Control Trial

Abstract

Overview

The present study explored the protective effects of moderate aerobic exercise against brain oxidative stress in rats exposed to radiofrequency electromagnetic radiation from cell phones.

Methods

• Investigated the responses of malondialdehyde, catalase, glutathione peroxidase, and superoxide dismutase.
• Measured the number of hippocampal dead cells in rats.
• Experiment involved four groups of male Wistar rats including exercise, radiation exposure, both, and control group.

Findings

Significant increase in hippocampal dead cells and malondialdehyde concentration was observed in the radiation exposure group compared to other groups. Conversely, the activity of catalase, glutathione peroxidase, and superoxide dismutase was higher in the exercise, combined exercise and radiation, and control groups.

Conclusion

This study confirms that moderate aerobic exercise can enhance the antioxidant capacity of the hippocampus, providing neuroprotection against the oxidative stress induced by radiofrequency electromagnetic waves.