Abstract

Overview

The increase in mobile phone usage worldwide necessitates investigations into the effects of electromagnetic radiation (EMR) on biological tissues, particularly brain proteomes. This study explores the global proteome profile changes in the rat hippocampus following prolonged exposure to mobile phone radiation.

Methodology

• Duration: 20 weeks exposure (3 hours/day for 5 days/week).
• Sample: Rat hippocampus tissue.
• Analysis Techniques: Proteome profiling and western blot validation.

Findings

We identified 358 proteins in the hippocampus, with 16 proteins showing significant deregulation that contributed to three main molecular pathways:

• Energy Metabolism: Aldh5a1
• Membrane Transport: Atp1b2, PMCA
• Neuroprotection: Protein S100B

These findings were validated through western blot analysis in an independent sample set.

Conclusion

The study presents concerning evidence that mobile phone radiation can alter the hippocampus proteome, potentially influencing brain function. The deregulated proteome could represent an adaptive response to restore neuronal function under EMR exposure, underscoring the need for careful consideration of mobile phone usage impacts on health, especially in relation to human brain function.