Abstract

Overview

With modern children and adolescents consistently using mobile phones and consuming high-fructose diets, coinciding increases in insulin resistance and fatty liver syndrome among young adults have sparked health concerns.

Objective

This study examines the effects of electromagnetic field (EMF) exposure from mobile phones combined with high fructose intake during crucial developmental stages on energy regulation signals from the hypothalamus and liver in rats.

Methodology

• Four experimental groups were used: Normal, Exposure Only (ExpO), Fructose Only (FruO), and Exposure with Fructose (EF).
• Weaned rats were subjected to either normal chow or fructose-enriched diets combined with EMF exposure (2 hours/day) over 8 weeks.

Findings

The EF group showed increased calorie consumption and weight gain triggered by elevated ghrelin levels. This group also experienced reduced insulin sensitivity, altered lipid profiles, and fatty liver development by early adulthood.

• Notable metabolic disturbances included inhibited glycolysis and stimulated gluconeogenesis.
• Marked changes were observed in the expression of hypothalamic and hepatic glucosensors and energy regulation peptides such as NPY and POMC.

Conclusion

The study provides compelling evidence that EMF exposure from mobile phones, coupled with unregulated fructose consumption during childhood and adolescence, detrimentally affects the crucial glucoregulation and satiety mechanisms by early adulthood.