Combined effect of co-exposure to di (2-ethylhexyl) phthalates and 50-Hz magnetic-fields on promoting human amniotic cells proliferation

Authors: Liangjing Chen, Anfang Ye, Xiaochen Liu, Jingchun Lu, Qixin Xie, Yixin Guo, Wenjun Sun

Year: 2021 Aug 26

Category: Environmental Toxicology

Journal: Ecotoxicology and Environmental Safety

Institution: Ecotoxicol Environ Saf

DOI: 10.1016/j.ecoenv.2021.112704

URL: https://pubmed.ncbi.nlm.nih.gov/34455183/

Abstract

Overview

Di (2-ethylhexyl) phthalate (DEHP) and extremely low-frequency electromagnetic fields (ELF-EMFs) are prevalent in our environment. Previous studies have shown that both DEHP and ELF-EMFs may stimulate cell proliferation, which is associated with negative biological effects.

Findings

In this research, the interaction between DEHP and 50-Hz magnetic fields (MFs) on cell proliferation in human amniotic (FL) cells was examined.
Low-concentration DEHP (1 μM) enhanced FL cell proliferation, while high-dose DEHP (100 μM) reduced it.
Significantly higher proliferation rates were observed in FL cells when treated jointly with a 50-Hz, 0.2-mT MF and 0.1 μM DEHP compared to exposure to a single factor.

Conclusion

Co-exposure to under-threshold MF and DEHP can cooperatively trigger key signaling pathways such as protein kinase B (Akt), sphingosine kinase 1 (SphK1), and extracellular signal-regulated kinase (ERK), culminating in enhanced cell proliferation. These findings underscore the importance of being cautious when assessing potential health risks associated with low-level exposure to MFs and DEHP.

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