Abstract

Overview

The study explores the biological impacts of extremely low-frequency electromagnetic field (ELF-EMF) exposure, focusing on human amniotic epithelial cells.

Findings

• Previous discoveries showed the involvement of L-type calcium channel and sphingosine kinase 1 (SK1) in 50-Hz MF exposure-induced cell proliferation.
• The current research further identifies the critical role of intracellular Ca2+ and related signal molecules in promoting cell growth under 50-Hz MF exposure.
• Key experiments demonstrated that Ca2+ chelators could inhibit MF-induced cell proliferation, highlighting the essential role of Ca2+ in these cellular processes.
• The role of various inhibitors like BAPTA (calcium chelator) and SKI II on MF-induced activation of the Akt-SK1 pathway and subsequent cell proliferation were elucidated.

Conclusion

The study concludes that endogenous Ca2+ release significantly contributes to the 50-Hz MF-induced cell proliferation via the Akt-SK1 signaling cascade. This signals potential health risks associated with 50-Hz MF exposure at a cellular level.