Abstract

Overview

Mesenchymal stem cells (MSCs) are highly regarded in regenerative medicine for their multipotency and immunomodulatory attributes. This study examines the influence of super-low-intensity microwave radiation on MSCs, highlighting its potential role in their functions and applications.

Findings

• Exposure to microwave radiation significantly alters MSC behavior through non-thermal mechanisms, notably affecting calcium signaling and mitochondrial activity.
• This exposure facilitates increased MSC proliferation, differentiation, and secretion of paracrine factors.
• Significant implications for enhancing MSC capabilities in treating conditions like myocardial infarction, osteoarthritis, and brain damage are demonstrated in preclinical models.

Conclusion

Further research is necessary to optimize microwave treatment parameters and to ensure safety, aiming for clinical translation. If validated for safety and efficacy, microwave-enhanced MSC therapy could lay new groundwork for cell-based treatments in regenerative medicine.