Assessment of Inflammation in 3D Reconstructed Human Skin Exposed to Combined Exposure to Ultraviolet and Wi-Fi Radiation

Abstract

Overview

In contemporary human environments, exposure to radiofrequency (RF) emitted by wireless devices is increasing, which is mostly absorbed by the skin and superficial soft tissues. This study examines the impact of Wi-Fi frequency at 2422 MHz combined with ultraviolet (UV) radiation on human skin inflammation.

Findings

• The known detrimental impact of solar UV radiation, such as genotoxic, cytotoxic, and mutagenic effects on skin is acknowledged.
• The study utilized a 3D full-thickness human skin model to evaluate inflammation by analyzing cytokines (IL-1α, IL-6, IL-8) and MMP-1 enzyme secretion.
• One scenario examined immediate RF exposure following UV exposure to detect potential additive effects.
• Another scenario explored the adaptive response where RF exposure was followed by UV radiation to investigate potential protective effects.

Conclusion

The research indicates that exposure to 2422 MHz Wi-Fi slightly increased cytokine concentrations following UV exposure, but the changes were not significant, and no adaptive response was observed.