Protocol for a systematic review of the in vivo studies on radiofrequency (100 kHz-300 GHz) electromagnetic field exposure and cancer

Authors: Pinto R, Ardoino L, Giardullo P, Villani P, Marino C

Year: 2022 Feb 16

Category: Epidemiology

Journal: Syst Rev

Institution: ENEA

DOI: 10.1186/s13643-022-01898-4

URL: https://pubmed.ncbi.nlm.nih.gov/35172887/

Abstract

Overview

An Italian project, led by the ENEA team, is undertaking a systematic review to explore the potential carcinogenic effects of radiofrequency electromagnetic field (RF-EMF) exposure. This review focuses on in vivo studies examining exposures within or above legal limits.

Objectives

The main aims of this comprehensive review include:

  • Providing descriptive and, if possible, quantitative summaries of RF-EMF studies.
  • Evaluating the consistency of these studies' observations.
  • Assessing the heterogeneity causes.
  • Analyzing the evidence weight to confirm or deny RF-EMF's carcinogenic effects.
  • Determining the potential carcinogenic risks associated with RF-EMF.

Methods

Methodologies involve:

  • Searching relevant studies across electronic academic databases and referenced literature since 2011.
  • Including experimental studies on rodents concerning various cancers and tumor-related outcomes.
  • Implementing a risk of bias assessment using a tool developed for animal studies.
  • Performing a meta-analysis, if feasible, or otherwise providing a narrative synthesis of the findings.

Findings and Conclusion

This protocol is registered with PROSPERO and adheres to the NTP OHAT Approach framework for systematic reviews, leading to the first strength of evidence assessment concerning RF-EMF and cancer. The ENEA team's multidisciplinary expertise is crucial in evaluating RF-EMF's carcinogenic potential.

electromagnetic fields carcinogenicity radiofrequency systematic review meta-analysis in vivo studies cancer risk
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