Abstract

Overview

An Italian project aims to review the scientific literature on the possible carcinogenicity of radiofrequency electromagnetic field (RF-EMF) exposure. The systematic review, led by the ENEA team, intends to explore the in vivo studies focusing on RF-EMF and its potential link to cancer development.

Objectives

• Development of a protocol for systematic review and meta-analysis to examine the carcinogenic risk of RF-EMF exposure above or within legal limits.
• Provide a descriptive and quantitative summary of the RF-EMF studies, evaluate consistency and heterogeneity of findings, and assess the strength of evidence regarding the carcinogenic effects of RF-EMF exposure.

Methods

We will search for relevant studies in electronic academic databases and in the reference list of selected papers and reviews, focusing on studies involving rodents of various genetic backgrounds and ages, exposing them to RF-EMF alone or combined with other agents. The review will include peer-reviewed articles in English with no publication date limit, assessing cancer-related outcomes.

Systematic Review Registration

The protocol is registered in PROSPERO with the number CRD42020191105.

Conclusion

This systematic review aims to provide a consolidated understanding of the carcinogenic potential of RF-EMF, utilizing the NTP OHAT Approach for systematic review to organize the investigation and clarify the association between RF-EMF exposure and cancer development.