Abstract

Overview

This study evaluates the impact of exposure to radiofrequency electromagnetic field (RF-EMF) on the placental barrier of pregnant rats, exploring how this exposure affects maternal and fetal stress markers.

Findings

• Pregnant Sprague-Dawley rats were assigned into three groups: cage-control, sham-exposed, and RF-exposed.
• Exposure was set at a whole-body specific absorption rate of 4 W/kg for 8 hours daily from gestational Day 1 to 19.
• Significant increases in cortisol levels in both circulating blood and the adrenal gland were noted in the RF-exposed group compared to sham.
• No change was observed in placental cortisol stability and 11β-HSD2 mRNA levels in the placenta.
• Morphological examinations and measurements of fetal placental parts revealed no significant alterations due to RF-EMF exposure.

Conclusion

While RF-EMF exposure significantly raised cortisol levels, suggesting potential stress enhancements in pregnant rats, it did not alter the protective barrier function of the placenta in this model. This raises questions about EMF safety concerning maternal stress during pregnancy and its implications for fetal development.