Protocol for a systematic review of the in vivo studies on radiofrequency (100 kHz–300 GHz) electromagnetic field exposure and cancer

Abstract

Overview

An Italian project is conducting a thorough examination of worldwide scientific literature to explore the potential link between radiofrequency (100 kHz–300 GHz) electromagnetic field (RF-EMF) exposure and cancer development. This work is carried out by the ENEA team.

Objectives

• Develop a systematic review protocol, including meta-analysis, to assess the carcinogenic risks of RF-EMF exposure both above and within the legal limits.
• Provide both descriptive and quantitative analyses of past experiments and assess the consistency and causes of observation heterogeneity.
• Evaluate the evidence regarding the carcinogenic effects of RF-EMF, drawing conclusions on its potential cancer-causing capabilities.

Methods

The review will harness data from electronic academic databases and reference lists of relevant papers and reviews published since 2011. It focuses on experimental studies involving rodents exposed to RF-EMF either alone or alongside other agents.

Peer-reviewed papers in English without publication date limits are considered, and a risk of bias assessment will be employed specifically developed for animal studies. Where possible, meta-analyses will be conducted; otherwise, results will be synthesized narratively.

Conclusion

This review aims to substantially enhance our understanding of the potential health risks associated with RF-EMF exposure, guiding future research and public health policy.