Abstract

Overview

Impaired apoptosis is a critical feature in cancer development, and strategies to induce apoptosis are central to non-surgical cancer treatments. This review examines the interactions between extremely low-frequency magnetic fields (ELF-MF) and apoptosis processes in cells.

Findings

• Numerous studies suggest that non-ionizing, non-thermal ELF-MF may impact the induction of apoptosis in exposed cells, though findings vary widely.
• In the presence of additional stressors such as chemotherapeutic agents or ionizing radiation, ELF-EMF may enhance or reduce the apoptotic capabilities of these agents.
• The key to understanding these conflicting observations may lie in the cellular stress responses elicited by ELF-EMF exposure and their interactions with apoptotic mechanisms.

Conclusion

The paper aims to elucidate the complex relationship between ELF-EMF exposure, cellular stress responses, and apoptosis. Understanding these mechanisms can help integrate disparate observations and potentially lead to refined therapeutic protocols that utilize ELF-EMF in cancer treatment.