Abstract

Overview

This study investigates the effects of weak radio frequency (RF) fields on HT-1080 human fibrosarcoma cells, with a focus on oxidative stress and antioxidant responses.

Findings

• Exposure to 2-5 MHz RF fields at intensities of 20 nT over four days shows frequency-specific effects on HT-1080 cells.
• Increase in key antioxidants such as superoxide dismutase (SOD) and glutathione (GSH) at frequencies around 4-4.5 MHz, improving mitochondrial function and cell viability.
• Lower frequencies (2.5 MHz) increase oxidative stress, shown by GSH depletion and higher mitochondrial superoxide levels.
• Insights from the radical pair mechanism (RPM) suggest significant modulation of reactive oxygen species (ROS) and antioxidants.

Conclusion

The study demonstrates that RF fields have the potential to be used therapeutically to selectively modulate oxidative stress in cancer cells, which might help in addressing age-related diseases as well. Further investigation into RF fields could lead to the reassessment of current safety standards and therapeutic approaches.