Extremely low-frequency electromagnetic field (ELF-EMF) induces alterations in epigenetic regulation in the myometrium - An in vitro study

Authors: Franczak A, Drzewiecka EM, Kozlowska W, Zmijewska A, Wydorski PJ

Year: 2023 Feb 7

Category: Epigenetics

Journal: Theriogenology

DOI: 10.1016/j.theriogenology.2023.02.005

URL: https://pubmed.ncbi.nlm.nih.gov/36806924/

Abstract

Overview

This study explores the impact of extremely low-frequency electromagnetic fields (ELF-EMFs) on epigenetic mechanisms within the myometrium using in vitro methods.

Findings

  • Hypothesized Influence: The study posits ELF-EMF could alter epigenetic regulation of gene expression in the myometrium.
  • Experimental Setup: Investigated the myometrium from porcine during the peri-implantation period under ELF-EMF exposure (50 Hz, 8 mT, 2 hours).
  • Key Molecular Changes: Observed increase in DNMT1, decrease in DNMT3a mRNA and protein levels, and an increase in genomic DNA methylation.
  • Expression Changes: Studied changes in promoter regions and transcriptional activity of genes such as PDYN, IL15, STAT5A, TNF, EGR2, HAPLN1, and UABP2 in response to ELF-EMF.

Conclusion

ELF-EMF exposure leads to significant epigenetic alterations, suggesting a potential mechanism by which ELF-EMF could affect myometrial gene expression and imply health risks associated with ELF-EMF exposure.

ELF-EMF epigenetic regulation myometrium DNA methylation gene expression
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