Exposure to the electromagnetic field alters the transcriptomic profile in the porcine endometrium during the peri-implantation period

Authors: Kozlowska W, Drzewiecka EM, Paukszto L, Zmijewska A, Wydorski PJ, Jastrzebski JP, Franczak A

Year: 2021 Dec

Category: Pharmacology

Journal: J Physiol Pharmacol

DOI: 10.26402/jpp.2021.6.04

URL: https://www.jpp.krakow.pl/journal/archive/12_21/pdf/10.26402/jpp.2021.6.04.pdf

Abstract

Abstract Summary

Overview: The research highlight the influence of low-frequency electromagnetic fields (EMF) as an environmental pollutant that could impact female reproduction.

Findings: The study primarily focused on the effects of EMF (50 Hz for 2 hours) on the endometrium of pigs during the peri-implantation period in vitro. A significant alteration was observed in the transcriptomic profile of the treated endometrium compared to the untreated control.

  • 1561 transcriptionally active regions (TARs) were altered due to EMF.
  • Out of 461 evaluated differentially expressed genes (DEGs), 156 were upregulated and 305 were downregulated.
  • The study also highlighted the identification of 210 long noncoding RNAs (lncRNAs) with changes in expression profiles and 146 predicted RNA editing sites.

Conclusion: EMF exposure affects gene expression linked to proliferation and metabolism in the endometrium, which could further impact fertility and pregnancy outcomes. The findings advocate for more detailed studies on EMF's molecular impacts during critical reproductive phases.

EMF transcriptomic profile porcine endometrium peri-implantation female reproduction RNA editing gene expression
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