Electromagnetic field exposure alters in vitro estrogen biosynthesis and its release by the porcine endometrium in the peri-implantation period

Authors: Wiktoria Kozlowska, Ewa Monika Drzewiecka, Agata Zmijewska, Anita Franczak

Year: 2022 Apr 26

Category: Reproductive Biology

Journal: Reprod Biol

DOI: 10.1016/j.repbio.2022.100642

URL: https://www.sciencedirect.com/science/article/pii/S1642431X22000419?via%3Dihub

Abstract

Overview

The study investigates the potential impact of Electromagnetic Field (EMF) exposure on estrogen synthesis and release during the critical peri-implantation period in pigs, emphasizing environmental safety concerns.

Findings

  • The research focuses on the effects of EMF at frequencies of 50 Hz and 120 Hz over durations of 2 or 4 hours.
  • Variables include the presence and absence of progesterone (P4) treatment, aiming to explore if P4 could provide protective effects against EMF.
  • Significant findings noted increased mRNA transcript abundance related to estrogen synthesis in select conditions of EMF exposure and P4 treatment.
  • Exposure to EMF varied the levels of critical enzymes and proteins, disrupting normal estrogen biosynthesis and release.

Conclusion

EMF exposure is confirmed as an environmental risk factor that potentially disrupts hormone synthesis, stressing the critical need for comprehensive policies and protective measures against EMF exposure.

EMF estrogen biosynthesis endometrium peri-implantation porcine environmental risk hormonal alteration
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