Abstract

Overview

This study explores the impact of electromagnetic fields (EMF) on reproductive processes in pigs, specifically focusing on the early stages of pregnancy and interactions with androgen synthesis in the myometrium.

Findings

• Low, non-ionizing EMF radiation was applied to myometrial slices at frequencies of 50 Hz and 120 Hz over periods of 2 and 4 hours.
• Tests were conducted to observe changes in mRNA transcript abundance of aromatase cytochrome P450 17α-hydroxylase/C17-20lyase (CYP17A1) and 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (HSD3B1).
• Additionally, the study measured the cytochrome P450c17 and 3β-HSD protein abundance along with the secretion of androgens such as androstenedione (A4) and testosterone (T).
• Results indicate significant alterations in both cellular densities and androgen secretion, attributed to EMF exposure’s frequency and duration.

Conclusion

EMF radiation notably affects cytochrome and androgen levels in the myometrium during the peri-implantation period. Importantly, progesterone (P4), tested as a protective measure, did not prevent alterations caused by EMF exposure.