Therapeutic effects of melatonin in long-term exposure to 2100MHz radiofrequency radiation on rat sperm characteristics

Authors: Özgen M, Take G, Kaplanoğlu İ, Erdoğan D, Seymen CM

Year: 2023 Jul 4

Category: Biomedical Research

Journal: Rev Int Androl

Institution: Rev Int Androl

DOI: 10.1016/j.androl.2023.100371

URL: https://pubmed.ncbi.nlm.nih.gov/37413938/

Abstract

Overview

Introduction: Radiofrequency electromagnetic fields (RF-EMFs) are recognized as potential risk factors for male reproductive health. The study explores melatonin's protective potential against RF-EMF-induced male fertility issues due to its antioxidant properties.

Methods

Wistar albino rats were divided into four groups for a 90-day study period: Control, Melatonin (10mg/kg, subcutaneously), RF (2100MHz, 30 minutes per day, whole-body exposure), and RF+Melatonin groups.
Assessment of sperm characteristics was conducted through analysis of sperms at the ultrastructural level, measuring aspects like the perinuclear ring and the posterior portion of the nucleus (ARC).

Findings

Results indicated significant increases in abnormal sperm morphology and decreases in total sperm count due to RF exposure. Notably, RF had deleterious effects on sperm structure components such as the acrosome, axoneme, mitochondrial sheath, and outer dense fibers. Conversely, melatonin treatment reversed these effects, restoring normal morphology and total sperm count.

Conclusion

The findings support melatonin’s efficacy as a therapeutic agent in mitigating the reproductive impairments related to long-term exposure to 2100MHz RF radiation.

melatonin radiofrequency radiation sperm characteristics reproductive health male fertility therapeutic development rat study

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