Effects of 2600 Mhz RF Radiation and Melatonin on Skin and Liver Tissue Hydroxyprolin Levels of Male Rats

Abstract

Overview

The present study investigates the impact of 2600 MHz radiofrequency radiation (RFR) and melatonin treatment on hydroxyproline levels in the skin and liver tissues of male rats.

Methods

• RFR exposure was achieved using a Rohde & Schwartz Radiofrequency signal generator and ETS-Lindgren horn antenna.
• 36 male Wistar albino rats were divided into six groups: Control, sham, RFR, control + Melatonin, Sham + Melatonin, and RFR + Melatonin.
• Exposures were for 30 minutes per day, 5 days per week, for 30 days with an average electric field value of 21.74 V/m.
• Melatonin was administered subcutaneously at a dose of 10 mg/kg for the same period.

Findings

The study revealed that:

• Hyp levels in skin tissue significantly decreased in the RFR-exposed groups compared to the control and sham groups.
• Additionally, a further decrease was observed in the RFR + melatonin treated group compared to both the control group and those treated only with melatonin.
• No significant changes were noted in the liver tissue Hyp levels.

Conclusion

Exposure to RFR resulted in significant alterations in skin tissue hydroxyproline levels, indicating a potential risk factor for skin health, possibly related to the proximity of the skin tissue to the radiation source. These findings underscore the need for careful consideration of skin exposure to RFR, especially when combined with agents like melatonin.