Therapeutic effects of melatonin in long-term exposure to 2100MHz radiofrequency radiation on rat sperm characteristics

Authors: Özgen M, Take G, Kaplanoğlu İ, Erdoğan D, Seymen CM

Year: 2023 Jul 4

Category: Reproductive Health

Journal: Rev Int Androl

Institution: Rev Int Androl

DOI: 10.1016/j.androl.2023.100371

URL: https://pubmed.ncbi.nlm.nih.gov/37413938/

Abstract

Overview

Introduction: Radiofrequency electromagnetic fields (RF-EMFs) are recognized as potential risk factors for male reproductive health. Melatonin, known for its antioxidant properties, is being studied as a possible therapeutic solution to combat RF-induced male fertility issues.

Methodology

The experimental design included Wistar albino rats divided into four groups, with treatments continuing for ninety consecutive days. The groups were:

  • Control group
  • Melatonin treated (10mg/kg, subcutaneously)
  • RF exposed (2100MHz, thirty minutes per day, whole-body)
  • Combined RF and Melatonin treatment
Observations involved sperm count and detailed ultrastructural sperm analysis.

Findings

Key findings revealed:

  • Significant increase in abnormal sperm morphology due to RF exposure.
  • Decrease in total sperm count under RF conditions.
  • A negative impact on several sperm structural components such as acrosome and mitochondrial sheath.
  • Improvements in sperm count and morphology when treated with melatonin.

Conclusion

The study supports the potential of melatonin as a therapeutic agent to mitigate reproductive harm caused by long-term exposure to 2100MHz RF radiation.

EMF radiofrequency radiation melatonin reproductive health sperm characteristics rat study
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