Abstract

Overview

The study investigates the protective effects of Rosmarinic Acid (RA) against oxidative stress induced by Ultra-High Frequency (UHF) waves in rats, commonly generated by cell phones.

Methods

• Forty-two male Wistar rats were divided into six groups.
• Groups were exposed to different conditions: control with saline, cell phone radiation at 915 MHz, UHF waves at 2450 MHz, and combinations of RA with these frequencies.
• Dosage for RA was 20 mg/kg, and the exposure lasted for 30 days.
• Measures included biochemical and histopathological parameters of rat testes.
• Analysis was performed using ANOVA and Tukey's post hoc test.

Findings

• Significant reductions in antioxidant enzyme activity and glutathione content due to cell phone and UHF wave exposure (P<0.001).
• Increase in oxidative stress indices such as malondialdehyde, nitric oxide, and protein carbonyl from UHF exposure (P<0.001).
• UHF radiation severely affected testicular structure, including reductions in cell types and tunica dimensions (P<0.001).
• Conversely, RA administration mitigated these adverse effects, improving both biological and histological parameters significantly (P<0.001).

Conclusion

Rosmarinic Acid (RA) significantly protects rat testes from the toxicity induced by UHF radiation, suggesting potential benefits as a dietary supplement for humans in UHF-polluted environments.