Comparison of the Effects of Rosmarinic Acid and Electromagnetic Radiation-Induced Cardiotoxicity on Rats

Authors: Goudarzi M, Fatahi Asl J, Shoghi H

Year: 2023

Category: Cardiology

Journal: J Tehran Heart Cent

Institution: J Tehran Heart Cent

DOI: 10.18502/jthc.v18i3.14115

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10748653/

Abstract

Overview

The study investigates the cardio-protective properties of Rosmarinic Acid (RA) against Electromagnetic Radiation (EMR)-induced cardiotoxicity in male Wistar rats.

Background

  • EMR is known to cause the stable aggregation of reactive oxygen species (ROS), leading to oxidative stress.
  • RA, a plant-origin antioxidant, has been studied for its potential protective effects against the side effects of various EMR frequencies.

Methods

Forty-two male Wistar rats were divided into six groups, subjected to different treatments of normal saline, EMR (915 MHz and 2450 MHz), and RA in combination with EMR for 30 days.

Results

  • EMR exposure significantly reduced levels of several antioxidants in the body and increased oxidative stress indicators.
  • RA treatment improved antioxidant levels and reduced oxidative stress markers in groups exposed to EMR.
  • Significantly, the treatment also reversed the cardiac damage markers in EMR exposed rats, indicating a protective effect of RA.

Conclusion

RA shows significant protective effects against EMR-induced cardiotoxicity, suggesting its potential therapeutic role in conditions generated by high-frequency electromagnetic exposure.

cardiotoxicity electromagnetic radiation rosmarinic acid oxidative stress rat model
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