Comparison of the Effects of Rosmarinic Acid and Electromagnetic Radiation-Induced Cardiotoxicity on Rats

Abstract

Overview

The study examines the cardiotoxic effects of electromagnetic radiation (EMR) and the protective role of rosmarinic acid (RA), an antioxidant derived from plants, on male Wistar rats.

Background

• EMR is known to cause an aggregation of reactive oxygen species (ROS), leading to oxidative stress.
• Rosmarinic acid has been suggested to mitigate the adverse effects associated with cell phone and ultrahigh-frequency wave exposures.

Methods

Forty-two male Wistar rats were assigned into six different groups to receive various treatments involving EMR and RA over a period of 30 days, with exposure lasting one hour per day.

Findings

• Significant reductions in the antioxidant enzymes’ activities such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were noted due to EMR exposure.
• Increased oxidative stress markers, including malondialdehyde (MDA) and nitric oxide (NO), were observed in EMR-exposed groups.
• Conversely, the administration of RA demonstrated a notable improvement in total antioxidant capacity and reduced oxidative stress markers.

Conclusion

Rosmarinic acid significantly counteracts the cardiotoxic effects induced by EMR, suggesting its potential as a protective agent against EMR-related oxidative stress in cardiac tissues.