Abstract

Overview of the Study

Rosmarinus officinalis L., commonly known as rosemary, is a source of rosmarinic acid (RA). This study evaluates the effectiveness of RA in combating oxidative stress in rat brains caused by radio frequency (RF) radiation from mobile phones and Wi-Fi, which operate at 915 MHz and 2450 MHz, respectively.

Methods Employed

• Rats were divided into six groups receiving different treatments, including normal saline and RA combined with exposure to RF radiation.
• Exposure was set at 60 minutes per day for a duration of one month.

Key Findings

Increased Stress Markers: Exposure to RF radiation significantly increased levels of protein carbonylation (PC), nitric oxide (NO), and malondialdehyde (MDA), and decreased antioxidant enzymes in the brain.

Protective Effects of RA: Administration of RA markedly reduced harmful oxidative markers (NO, PC, MDA) and enhanced total antioxidant capacity (TAC) and activities of enzymes like glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT).

Conclusion

RA shows potential as a protective agent against brain tissue damage from RF radiation-induced oxidative stress, suggesting it helps maintain balance in antioxidant enzyme activities and oxidative stress indicators.