Abstract

Overview

The study examines the increased use of mobile phones, which emit electromagnetic radiation (EMR) that disturbs cellular processes via oxidative stress. L-cysteine, a precursor to glutathione, was studied for its potential to prevent this oxidative damage.

Research Design

• Fabrication of transdermal patches (TDPs) with L-cysteine hydrochloride and sorbitol in synthetic silicone matrices.
• Investigation of sorbitol's effect on patch properties and L-cysteine release and permeation.
• Evaluation of the patches in a rat model for their effect on blood and brain tissue under mobile phone EMR exposure.

Findings

The addition of sorbitol enhanced the patch's plasticity, release rate of L-cysteine, and skin permeation. The pharmacokinetic studies indicated that these patches helped maintain sustained glutathione levels, potentially countering the damaging effects of EMR.

Conclusion

The study suggests that L-cysteine loaded patches could represent a promising long-term strategy to mitigate the risks associated with mobile phone radiation. Significant differences were observed in the biological parameters of treated rat groups when compared to controls.