Panax ginseng Ameliorates Pituitary-Ovarian Dysfunction Induced by RF EMR from Cell Phones via Upregulation of the CREM Signaling Pathway

Authors: Oyewopo OA, Badejogbin OC, Ajadi IO, Enye LA, Ajadi MB, Ebuwa IV, Owolabi OV, Areloegbe SE, Olaniyi KS

Year: 2024 Apr 30

Category: Pharmacology

Journal: Curr Drug Discov Technol

DOI: 10.2174/0115701638279386240425050818

URL: https://pubmed.ncbi.nlm.nih.gov/38693729/

Abstract

Overview

Panax ginseng (PG) contains ginsenosides which are considered adaptogens that protect cells. This study explored whether PG could counteract pituitary-ovarian dysfunction influenced by Radiofrequency Electromagnetic Radiation (RF-EMR) from mobile phones in rat models, via a CREM-dependent pathway.

Methods

  • Twenty adult female Wistar rats were divided into four groups of five.
  • Control group: received distilled water orally.
  • P. ginseng group: received 200 mg/kg of P. ginseng extract orally.
  • RF-EMR group: exposed to 900MHz radiation.
  • RF-EMR + PG group: exposed to radiation and treated with 200 mg/kg of P. ginseng.
  • Treatments were administered daily for 56 days.

Findings

The RF-EMR group showed significant reductions in serum hormone levels and antioxidant enzymes, alongside a decrease in the expression of the CREM gene and disrupted gland morphology. However, treatment with P. ginseng mitigated these effects.

Conclusion

The study concludes that P. ginseng extract provides protection against pituitary-ovarian impairment from RF-EMR, enhancing antioxidant capacity and promoting a CREM-dependent pathway.

Panax ginseng pituitary-ovarian dysfunction RF EMR CREM signaling cellular protection infertility antioxidant
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