Panax ginseng Ameliorates Pituitary-Ovarian Dysfunction Induced by RF EMR from Cell Phones via Upregulation of the CREM Signaling Pathway

Authors: Oyewopo OA, Badejogbin OC, Ajadi IO, Enye LA, Ajadi MB, Ebuwa IV, Owolabi OV, Areloegbe SE, Olaniyi KS

Year: 2024 Apr 30

Category: Endocrinology, Reproductive Toxicology

Journal: Current Drug Discovery Technologies

DOI: 10.2174/0115701638279386240425050818

URL: https://pubmed.ncbi.nlm.nih.gov/38693729/

Abstract

Overview

Panax ginseng (PG) is well-regarded for its cellular-protective properties due to its ginsenoside content. However, its effects on pituitary-ovarian dysfunction and infertility, particularly those induced by radiofrequency electromagnetic radiation (RF-EMR) from cell phones, are not fully understood. This study explores whether PG can counteract pituitary-ovarian dysfunction associated with mobile phone RF-EMR in rat models and investigates the role of the cAMP Response Element Modulator (CREM) pathway.

Methods

  • Twenty adult female Wistar rats were divided into four groups (5 rats each):
    • Control group: received distilled water orally
    • P. ginseng group: received 200 mg/kg PG extract orally
    • RF-EMR group: exposed to 900MHz RF-EMR
    • RF-EMR + PG group: exposed to 900MHz RF-EMR + 200 mg/kg PG extract orally
  • Treatments were administered daily for 56 days.

Findings

  • The RF-EMR exposed group displayed significant reductions in serum levels of LH, FSH, estradiol, and progesterone versus controls.
  • Antioxidant enzymes (SOD, GPx) levels were markedly lower in the RF-EMR group.
  • CREM gene expression was notably decreased in the RF-EMR group, and the pituitary/ovarian morphology was disrupted.
  • Administration of Panax ginseng mitigated all these negative changes.

Conclusion

Panax ginseng extract effectively protects against pituitary-ovarian dysfunction associated with RF-EMR exposure (such as that from cell phones) by enhancing antioxidant activity and stimulating the CREM-dependent signaling pathway. This provides strong evidence for a link between electromagnetic field exposure and reproductive health risks, and indicates a promising protective role of Panax ginseng.

RF-EMR pituitary-ovarian dysfunction Panax ginseng CREM signaling pathway mobile phone radiation antioxidants infertility
← Back to Stats