Static Magnetic Field Induces Abnormality of Glucose Metabolism in rats' brain and results in anxiety-like behavior

Authors: Tang Shuo, Ye Yumeng, Yang Leilei, Hao Yanhui, Yu Chao, Yan Hua, Xing Yuan, Jia Zhaoqian, Hu Cuicui, Zuo Hongyan, Li Yang

Year: 2021 Feb 4

Category: Neuroscience

Journal: J Chem Neuroanat

DOI: 10.1016/j.jchemneu.2021.101923

URL: https://pubmed.ncbi.nlm.nih.gov/33549700/

Abstract

Overview

In a recent scientific investigation, fifty-four male Wistar rats were subjected to varying intensities of static magnetic fields (SMF) to assess its impact on their brain's glucose metabolism and behavioral patterns.

Methodology

  • The rats were divided into four groups based on SMF intensity: control, low-intensity (50 mT), moderate-intensity (100 mT), and high-intensity (200 mT).
  • Exposure was conducted using a superconducting magnet for 1 hour per day over a period of 15 days.

Findings

Glucose Metabolism: Evaluations using micro-positron emission tomography (micro-PET) showed modulated glucose metabolism primarily in the moderate-intensity SMF group, indicating a dependency on the intensity of the exposure.

Enzyme Expression: Key enzymes like hexokinase 1 (HK1) and 6-phosphate fructokinase-1 (PFK1) experienced significant reductions in the brain post SMF exposure.

Behavioral Analysis: The open field test (OFT) indicated a noticeable decrease in activity such as total distance moved and climbing, which correlates with SMF exposure.

Pathological Observations

Brain examinations revealed neuronal pyknosis, edema, and a slight widening of the perivascular space after repeated exposure.

Conclusion

This exhaustive study suggests a clear link between SMF exposure and significant alterations in glucose metabolism, enzyme activity, and overall behavior which may contribute to anxiety-like behaviors in rats. The results advocate for a deeper exploration into the implications of SMF exposure for human health.

electromagnetic fields glucose metabolism anxiety-like behavior rat study SMF exposure brain health neurobiology
← Back to Stats